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Lei-Dab7 (TFA)

Lei-Dab7 TFA is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM) . Lei-Dab7 TFA exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, Kv and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

Product Specifications

UNSPSC

12352209

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lei-dab7-tfa.html

Purity

99.75

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@]1([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@]2([H])C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@](C(N[C@@](C(NCC(NC(C(NC(C(N[C@@](C(N[C@H](C(N[C@@H](CSSC2)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CC3=CN=CN3)=O)=O)=O)=O)CCC(O)=O)=O)([H])CSSC1)=O)CCCCN)=O)CC(O)=O)=O)=O)([H])[C@@H](C)CC)=O)([H])CSSC4)=O)CCCCN)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)CC(C)C)=O)CO)=O)CCCNC(N)=N)=O)=O)CO)=O)CC(C)C)=O)CCC(N)=O)=O)=O)CCN)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(N)=O)[C@H]4NC([C@@H](NC([C@@H](N)C)=O)CC5=CC=CC=C5)=O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C141H236N46O39S6.xC2HF3O2

Molecular Weight

3392.06 (free base)

References & Citations

[1]Sabrine Aidi-Knani, et al. Correspondences between the binding characteristics of a non-natural peptide, Lei-Dab7, and the distribution of SK subunits in the rat central nervous system. Eur J Pharmacol. 2015 Apr 5;752:106-11.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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