Lei-Dab7 (TFA)
Lei-Dab7 TFA is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM) . Lei-Dab7 TFA exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, Kv and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.
Product Specifications
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lei-dab7-tfa.html
Purity
99.75
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@]1([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@]2([H])C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@](C(N[C@@](C(NCC(NC(C(NC(C(N[C@@](C(N[C@H](C(N[C@@H](CSSC2)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CC3=CN=CN3)=O)=O)=O)=O)CCC(O)=O)=O)([H])CSSC1)=O)CCCCN)=O)CC(O)=O)=O)=O)([H])[C@@H](C)CC)=O)([H])CSSC4)=O)CCCCN)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)CC(C)C)=O)CO)=O)CCCNC(N)=N)=O)=O)CO)=O)CC(C)C)=O)CCC(N)=O)=O)=O)CCN)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(N)=O)[C@H]4NC([C@@H](NC([C@@H](N)C)=O)CC5=CC=CC=C5)=O.OC(C(F)(F)F)=O.[x]
Molecular Formula
C141H236N46O39S6.xC2HF3O2
Molecular Weight
3392.06 (free base)
References & Citations
[1]Sabrine Aidi-Knani, et al. Correspondences between the binding characteristics of a non-natural peptide, Lei-Dab7, and the distribution of SK subunits in the rat central nervous system. Eur J Pharmacol. 2015 Apr 5;752:106-11.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog