Lei-Dab7 (TFA)
Lei-Dab7 TFA is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM) . Lei-Dab7 TFA exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, Kv and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.
Product Specifications
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lei-dab7-tfa.html
Purity
99.75
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@]1([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@]2([H])C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@](C(N[C@@](C(NCC(NC(C(NC(C(N[C@@](C(N[C@H](C(N[C@@H](CSSC2)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CC3=CN=CN3)=O)=O)=O)=O)CCC(O)=O)=O)([H])CSSC1)=O)CCCCN)=O)CC(O)=O)=O)=O)([H])[C@@H](C)CC)=O)([H])CSSC4)=O)CCCCN)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)CC(C)C)=O)CO)=O)CCCNC(N)=N)=O)=O)CO)=O)CC(C)C)=O)CCC(N)=O)=O)=O)CCN)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(N)=O)[C@H]4NC([C@@H](NC([C@@H](N)C)=O)CC5=CC=CC=C5)=O.OC(C(F)(F)F)=O.[x]
Molecular Formula
C141H236N46O39S6.xC2HF3O2
Molecular Weight
3392.06 (free base)
References & Citations
[1]Sabrine Aidi-Knani, et al. Correspondences between the binding characteristics of a non-natural peptide, Lei-Dab7, and the distribution of SK subunits in the rat central nervous system. Eur J Pharmacol. 2015 Apr 5;752:106-11.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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