Balixafortide (TFA)

Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC50s [1][2].

Product Specifications

Product Name Alternative

POL6326 (TFA)

UNSPSC

12352209

Target

Arrestin; CXCR

Type

Peptides

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/balixafortide-tfa.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(C(F)(F)F)O.O=C1[C@]2([H])N(CCC2)C([C@@H](NC([C@@H](NC([C@@H](NC([C@@]3([H])NC([C@@H](NC([C@@H](NC([C@@H](NC([C@]4([H])N(CCC4)C([C@@H](NC([C@@H](NC([C@@](CSSC3)([H])NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@]5([H])N1CCC5)=O)CC6=CC=C(C=C6)O)=O)CC7=CN=CN7)=O)C)=O)=O)CO)=O)C)=O)=O)CCN)=O)CCCNC(N)=N)=O)CC8=CC=C(C=C8)O)=O)=O)CC9=CC=C(C=C9)O)=O)CCC(N)=O)=O)CCCCN)=O

Molecular Formula

C86H119F3N24O23S2

Molecular Weight

1978.16

References & Citations

[1]Zimmermann J, et al. Anti-tumor cell activity and in vitro profile of the next generation CXCR4 antagonist Balixafortide. Ann Oncol. 2018 Oct;29 Suppl 8:viii103.|[2]Karpova D, et al. Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers-results of a dose escalation trial. J Transl Med. 2017 Jan 3;15 (1) :2.