SAR156497
SAR156497 (compound 47) is an Aurora inhibitor, with IC50 values of 0.6 nM and 1 nM for Aurora A and Aurora B, respectively. SAR156497 can also inhibit PDE3, with IC50 value of 4 μM. SAR156497 can be used in anticancer research[1].
Product Specifications
CAS Number
1256137-14-0
UNSPSC
12352005
Target
Aurora Kinase; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sar156497.html
Smiles
O=C1C([C@@H](C2=CC(OC3=NC4=CC=CC=C4N3)=CC=C2)C5=CN6)=C(CCC1)NC5=C6C(OCC)=O
Molecular Formula
C27H24N4O4
Molecular Weight
468.50
References & Citations
[1]Carry JC, et al. SAR156497, an exquisitely selective inhibitor of aurora kinases. J Med Chem. 2015 Jan 8;58 (1) :362-75.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A; Aurora B; PDE3
Frequently Asked Questions
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