Vilazodone (Hydrochloride)

Vilazodone Hydrochloride (EMD 68843 Hydrochloride) is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist.

Product Specifications

CAS Number

[163521-08-2]

Product Name Alternative

EMD 68843 (Hydrochloride) ; SB659746A (Hydrochloride)

UNSPSC

12352005

Hazard Statement

H361

Target

5-HT Receptor; Serotonin Transporter

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Vilazodone-Hydrochloride.html

Purity

99.94

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC(C1=CC2=C(C=CC(N3CCN(CCCCC4=CNC5=CC=C(C=C54)C#N)CC3)=C2)O1)=O.[H]Cl

Molecular Formula

C26H28ClN5O2

Molecular Weight

477.99

Precautions

H361

References & Citations

[1]Lee A. Dawson et al. Vilazodone: A 5-HT1A Receptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders CNS Neuroscience & Therapeutics Volume 15, Issue 2, pages 107-117, June 2009|[2]Reed CR, Kajdasz DK, Whalen H, Athanasiou MC, Gallipoli S, Thase ME. The efficacy profile of vilazodone, a novel antidepressant for the treatment of major depressive disorder. Curr Med Res Opin. 2012 Jan;28 (1) :27-39.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

5-HT1 Receptor; mLAG-3

Citation 01

Mol Pharmacol. 2023 Nov;104 (5) :230-238.|Arch Pharm (Weinheim) . 2024 May 30:e2400263.|Cell. 2025 Oct 24:S0092-8674 (25) 01131-6.|Nature. 2023 Dec;624 (7992) :672-681.|Prog Neuropsychopharmacol Biol Psychiatry. 2024 Mar 2:130:110911.