Sophocarpine
Sophocarpine is a PTEN activator and an inhibitor of PI3K/Akt, MEK/ERK, and NF-κB signaling pathways. Sophocarpine upregulates PTEN expression and inhibits PI3K/Akt phosphorylation, arrests tumor cell cycle and induces apoptosis. Sophocarpine inhibits MEK/ERK phosphorylation and VEGF secretion, reducing tumor cell migration. Sophocarpine can also inhibit NF-κB activation and p38 and JNK phosphorylation, reduce the expression of inflammatory factors such as iNOS and COX-2, and activate the Nrf2/HO-1 pathway to reduce oxidative stress. Sophocarpine has anti-tumor, anti-inflammatory, antioxidant and anti-apoptotic effects, and can be used in the research of cancers such as glioblastoma and colorectal cancer, inflammation-related diseases, and Doxorubicin (HY-15142A) -induced cardiac damage[1][2][3][4].
Product Specifications
CAS Number
[6483-15-4]
UNSPSC
12352005
Hazard Statement
H301
Target
Akt; Apoptosis; Autophagy; ERK; MEK; NF-κB; PI3K; PTEN
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sophocarpine.html
Purity
99.85
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)
Smiles
O=C1C=CC[C@]2([H])[C@@]3([H])CCCN4[C@@]3([H])[C@](CCC4)([H])CN21
Molecular Formula
C15H22N2O
Molecular Weight
246.35
Precautions
H301
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PI3K
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Phospho-RPS6KB2 (Ser370) Recombinant Antibody, FITC Conjugated
