P-gp inhibitor 23
P-gp inhibitor 23 (compound 14F) is a potent inhibitor of P-gp and CYP3A4, with the EC50 and IC50 of 28 nM and 223 nM, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Cytochrome P450; P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p-gp-inhibitor-23.html
Smiles
COC1=C(C=C(C(NC(C2=CC(C3=C(O2)C=CC=C3)=O)=O)=C1)C(NC4=CC=C(C=C4)C5CCN(CC6=CC(N7C=CN=C7)=CC=C6)CC5)=O)OC
Molecular Formula
C40H37N5O6
Molecular Weight
683.75
References & Citations
[1]Ahmed M Said, et al. Design, synthesis, molecular modeling, in vitro and in vivo biological evaluation of potent anthranilamide derivatives as dual P-glycoprotein and CYP3A4 inhibitors. Eur J Med Chem. 2024 May 11:273:116492.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP3A4
Frequently Asked Questions
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