PTACH
PTACH (NCH-51) is a potent HDAC inhibitor with IC50s of 48 nM, 32 nM, and 41 nM for HDAC1, HDAC4, and HDAC6, respectively. PTACH exerts potent growth inhibition against various cancer cells (EC50s of 1.1-9.1 μM) [1][2].
Product Specifications
CAS Number
848354-66-5
Product Name Alternative
NCH-51
UNSPSC
12352005
Hazard Statement
H318, H413
Target
HDAC; HIV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/PTACH.html
Purity
99.65
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C)C(SCCCCCCC(NC1=NC(C2=CC=CC=C2)=CS1)=O)=O
Molecular Formula
C20H26N2O2S2
Molecular Weight
390.56
Precautions
H318, H413
References & Citations
[1]Suzuki T, et al. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem. 2005 Feb 24;48 (4) :1019-1032.|[2]Ann Florence B Victoriano, et al. Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression. FEBS Lett. 2011 Apr 6;585 (7) :1103-11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC4; HDAC6; HIV-1
Available Sizes
Frequently Asked Questions
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