PTACH

PTACH (NCH-51) is a potent HDAC inhibitor with IC50s of 48 nM, 32 nM, and 41 nM for HDAC1, HDAC4, and HDAC6, respectively. PTACH exerts potent growth inhibition against various cancer cells (EC50s of 1.1-9.1 μM) [1][2].

Product Specifications

CAS Number

[848354-66-5]

Product Name Alternative

NCH-51

UNSPSC

12352005

Hazard Statement

H318, H413

Target

HDAC; HIV

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/PTACH.html

Purity

99.65

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C)C(SCCCCCCC(NC1=NC(C2=CC=CC=C2)=CS1)=O)=O

Molecular Formula

C20H26N2O2S2

Molecular Weight

390.56

Precautions

H318, H413

References & Citations

[1]Suzuki T, et al. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem. 2005 Feb 24;48 (4) :1019-1032.|[2]Ann Florence B Victoriano, et al. Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression. FEBS Lett. 2011 Apr 6;585 (7) :1103-11.