PYEEI
PYEEI is a phosphotyrosine-containing tetrapeptide binds to Src SH2 domain with the Kd of 100 nM and with the IC50 of 6.5 μM. pYEEI plays an important role in cancer research[1].
Product Specifications
CAS Number
198472-14-9
UNSPSC
12352209
Target
Src
Type
Peptides
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pyeei.html
Smiles
O=C(O)CC[C@H](NC([C@@H](N)CC1=CC=C(OP(O)(O)=O)C=C1)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(O)=O)[C@@H](C)CC)=O)=O
Molecular Formula
C25H37N4O13P
Molecular Weight
632.55
References & Citations
[1]R A Grucza, et al. Role of Electrostatic Interactions in SH2 Domain Recognition: Salt-Dependence of Tyrosyl-Phosphorylated Peptide Binding to the Tandem SH2 Domain of the Syk Kinase and the Single SH2 Domain of the Src Kinase. Biochemistry. 2000 Aug 22;39 (33) :10072-81.|[2]R A Grucza, et al. Role of Electrostatic Interactions in SH2 Domain Recognition: Salt-Dependence of Tyrosyl-Phosphorylated Peptide Binding to the Tandem SH2 Domain of the Syk Kinase and the Single SH2 Domain of the Src Kinase. Biochemistry. 2000 Aug 22;39 (33) :10072-81.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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