Chlorotoxin (TFA)
Product Specifications
UNSPSC Description
Chlorotoxin TFA is a peptide isolated from the venom of the scorpion Leiurus quinquestriatus, acts as a chloride channel blocker[1]. Anti-cancer activity[2].
Target Antigen
Chloride Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/chlorotoxin-tfa.html
Purity
98.53
Solubility
DMSO : 100 mg/mL (ultrasonic)|H2O : 33.33 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)NC1=O)C(NCC(NCC(N[C@@H](CCCCN)C(NCC(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H]2CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CCSC)C(N4[C@@H](CCC4)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC5=CC=C(C=C5)O)C(NCC(N6[C@@H](CCC6)C(N[C@H]7CCC(N)=O)=O)=O)=O)=O)NC2=O)C(N[C@@H](CC8=CC=CC=C8)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC9=CNC=N9)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@H]1CC(C)C)=O)NC7=O)C(N[C@@H](CC(O)=O)C(N[C@H]3CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N.OC(C(F)(F)F)=O
Molecular Weight
3995.71 (free base)
References & Citations
[1]DeBin JA, et al. Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion. Am J Physiol. 1993 Feb;264(2 Pt 1):C361-9.|[2]Ojeda PG, et al. Chlorotoxin: Structure, activity, and potential uses in cancer therapy. Biopolymers. 2016 Jan;106(1):25-36.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P0173B/Chlorotoxin-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P0173B/Chlorotoxin-TFA-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
Available Sizes
Curated Selection
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