GSK-1562590
GSK-1562590 is a uropeptide-II receptor antagonist with high affinity and selectivity. GSK-1562590 exhibits significant antagonistic activity in multiple bioassays and, in contrast, displays relatively sustained receptor binding times. GSK-1562590 can inhibit human urinary peptide-II-induced aortic contraction in rats in experiments, and its effect can last for at least 24 hours[1].
Product Specifications
CAS Number
1003877-55-1
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/gsk-1562590.html
Smiles
NC(C1=CC=CC(C(C=C2)=CC=C2[C@H](CN3CCCC3)N(C)C(CN4C5=CC(Cl)=C(Cl)C=C5OCC4=O)=O)=C1)=O
Molecular Formula
C30H30Cl2N4O4
Molecular Weight
581.49
References & Citations
[1]GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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