PF-06260933

PF-06260933 is an orally active and highly selective inhibitor of MAP4K4 with IC50s of 3.7 and 160 nM for kinase and cell, respectively.

Product Specifications

CAS Number

[1811510-56-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAP4K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/PF-06260933.html

Concentration

10mM

Purity

99.39

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

NC1=C(C2=CC=C(Cl)C=C2)C=C(C(C=N3)=CC=C3N)C=N1

Molecular Formula

C16H13ClN4

Molecular Weight

296.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Ammirati M, et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment. ACS Med Chem Lett. 2015 Oct 6;6 (11) :1128-33.|[2]Roth Flach RJ, et al. Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis. Nat Commun. 2015 Dec 21;6:8995.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MAP4K4/HGK

Available Sizes

Curated Selection

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