L-364918

L-364918 is a potent and selective oxytocin and arginine vasopressin antagonist with Ki values of 30, 1300, 2400 nM for OT, AVP-V1, AVP-V2, respectively. L-364918 has the potential for the research of preterm labor and disturbances in water balance[1].

Product Specifications

CAS Number

[122211-31-8]

UNSPSC

12352005

Target

Oxytocin Receptor; Vasopressin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/l-364918.html

Smiles

O=C1NC(C(CC)C)C(N2NCCCC2C(N3NCCCC3C(N(C(CC4=CC=CC=C4)C(N5CCCC5C(NC1CC6=CC=CC=C6)=O)=O)C)=O)=O)=O

Molecular Formula

C40H54N8O6

Molecular Weight

742.91

References & Citations

[1]Pettibone DJ, et al. A structurally unique, potent, and selective oxytocin antagonist derived from Streptomyces silvensis. Endocrinology. 1989 Jul;125 (1) :217-22.