LIN28 inhibitor LI71
LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC50: 7 μM) . LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC50: 27 μM) . LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum[1][2].
Product Specifications
CAS Number
[1357248-83-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MicroRNA; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Epigenetics
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/lin28-inhibitor-li71.html
Purity
98.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=C([C@@H]2NC3=C(C=CC=C3OCC)[C@@]4([H])[C@]2([H])CC=C4)C=C1
Molecular Formula
C21H21NO3
Molecular Weight
335.40
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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