Diminazene (aceturate)
Product Specifications
Product Name Alternative
Diminazene (diaceturate)
UNSPSC Description
Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties[1][2][3].
Target Antigen
Angiotensin-converting Enzyme (ACE); Parasite
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/diminazene-aceturate.html
Purity
99.16
Solubility
DMSO : 25 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(O)CNC(C)=O.N=C(C1=CC=C(/N=N/NC2=CC=C(C(N)=N)C=C2)C=C1)N.O=C(O)CNC(C)=O
Molecular Weight
515.52
References & Citations
[1]Kuriakose S, et al. Diminazene aceturate (Berenil) modulates the host cellular and inflammatory responses to Trypanosoma congolense infection. PLoS One. 2012;7(11):e48696.|[2]Kuriakose S, et al. Diminazene aceturate (Berenil), a new use for an old compound? Int Immunopharmacol. 2014 Aug;21(2):342-5.|[3]Castardeli C, et al. The ACE 2 activator diminazene aceturate (DIZE) improves left ventricular diastolic dysfunction following myocardial infarction in rats. Biomed Pharmacother. 2018 Nov;107:212-218.Cell Metab. 2022 Feb 7;34(3):424-440.e7.|Endocrine. 2021 Mar 30;1-9.|J Inflamm Res. 2023 Apr 17;16:1639-1652.|Radiat Res. 2022 Jul 29.|Research Square Preprint. 2021 Mar.|J Inflamm Res. 2023 Apr 17;16:1639-1652.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12404/Diminazene-aceturate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12404/Diminazene-aceturate-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
908-54-3
Available Sizes
Curated Selection
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