Diminazene (aceturate)

Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties[1][2][3].

Product Specifications

CAS Number

[908-54-3]

Product Name Alternative

Diminazene (diaceturate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Angiotensin-converting Enzyme (ACE) ; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/diminazene-aceturate.html

Purity

99.31

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(O)CNC(C)=O.N=C(C1=CC=C(/N=N/NC2=CC=C(C(N)=N)C=C2)C=C1)N.O=C(O)CNC(C)=O

Molecular Formula

C22H29N9O6

Molecular Weight

515.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Kuriakose S, et al. Diminazene aceturate (Berenil) modulates the host cellular and inflammatory responses to Trypanosoma congolense infection. PLoS One. 2012;7 (11) :e48696.|[2]Kuriakose S, et al. Diminazene aceturate (Berenil), a new use for an old compound? Int Immunopharmacol. 2014 Aug;21 (2) :342-5.|[3]Castardeli C, et al. The ACE 2 activator diminazene aceturate (DIZE) improves left ventricular diastolic dysfunction following myocardial infarction in rats. Biomed Pharmacother. 2018 Nov;107:212-218.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Trypanosoma

Citation 01

Cell Metab. 2022 Mar 1;34 (3) :424-440.e7.|Drug Deliv Transl Res. 2025 Oct 29.|Endocrine. 2021 May;72 (2) :340-348.|Int Immunopharmacol. 2025 Aug 11:164:115325.|Int J Radiat Oncol Biol Phys. 2025 Sep 16:S0360-3016 (25) 06272-8.|J Inflamm Res. 2023 Apr 17:16:1639-1652.|Radiat Res. 2022 Oct 1;198 (4) :325-335.|Research Square Preprint. 2021 Mar.|J Inflamm Res. 2023 Apr 17:16:1639-1652.