Bempedoic acid

Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor[1]. Bempedoic acid (ETC-1002) activates AMPK[2].

Product Specifications

CAS Number

[738606-46-7]

Product Name Alternative

ETC-1002; ESP-55016

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

AMPK; ATP Citrate Lyase

Type

Reference compound

Related Pathways

Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ETC-1002.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C(C)(C)CCCCCC(O)CCCCCC(C)(C)C(O)=O

Molecular Formula

C19H36O5

Molecular Weight

344.49

Precautions

H302, H312, H332

References & Citations

[1]Pinkosky SL, et al. AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism. J Lipid Res. 2013 Jan;54 (1) :134-51.|[2]Filippov S, et al. ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK. J Lipid Res. 2013 Aug;54 (8) :2095-108.