Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

CM-675

CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer’s disease[1].

Product Specifications

CAS Number

1872466-47-1

Product Name Alternative

ONO1101 (hydrochloride),BMS-189453

UNSPSC

12352005

Target

HDAC; Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cm-675.html

Concentration

10mM

Purity

99.53

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=CC=CC=C1N)C2=CC=C(CC3=CC=C(OCC)C(C4=NC5=C(N(C)N=C5CCC)C(N4)=O)=C3)C=C2

Molecular Formula

C31H32N6O3

Molecular Weight

536.62

References & Citations

[1]Rabal O, et al. Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1765-1782.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HDAC1; PDE5

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

GM CSF Receptor alpha (CSF2RA) Mouse Monoclonal Antibody [Clone ID: OTI2E12]
CF812525 100 µg

GM CSF Receptor alpha (CSF2RA) Mouse Monoclonal Antibody [Clone ID: OTI2E12]

Sign In for Pricing
View Details
Celsr1 Mouse Gene Knockout Kit (CRISPR)
KN503119 1 Kit

Celsr1 Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
Recombinant Human mastadenovirus B (HAdV-B) encapsidation protein IVa2 Recombinant (His Tag)
PKSV030212 100 µg

Recombinant Human mastadenovirus B (HAdV-B) encapsidation protein IVa2 Recombinant (His Tag)

Sign In for Pricing
View Details
GIPC (GIPC1) Mouse Monoclonal Antibody [Clone ID: OTI6A6]
CF811963 100 µg

GIPC (GIPC1) Mouse Monoclonal Antibody [Clone ID: OTI6A6]

Sign In for Pricing
View Details
QSOX2 Human Gene Knockout Kit (CRISPR)
KN416421 1 Kit

QSOX2 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
DDIT3 Rabbit Polyclonal Antibody
ER1803-20 100 µL

DDIT3 Rabbit Polyclonal Antibody

Sign In for Pricing
View Details