CM-675

CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer’s disease[1].

Product Specifications

CAS Number

[1872466-47-1]

Product Name Alternative

ONO1101 (hydrochloride),BMS-189453

UNSPSC

12352005

Target

HDAC; Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cm-675.html

Concentration

10mM

Purity

99.53

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=CC=CC=C1N)C2=CC=C(CC3=CC=C(OCC)C(C4=NC5=C(N(C)N=C5CCC)C(N4)=O)=C3)C=C2

Molecular Formula

C31H32N6O3

Molecular Weight

536.62

References & Citations

[1]Rabal O, et al. Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1765-1782.