Hydrocortisone-d7

Hydrocortisone-d7 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].

Product Specifications

Product Name Alternative

Cortisol-d7

UNSPSC

12352211

Hazard Statement

H360, H373

Target

Endogenous Metabolite; Glucocorticoid Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Inflammation/Immunology; Endocrinology; Cancer

Purity

99.91

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@](CC[C@]2(O)C(C([2H])([2H])O)=O)([H])[C@@]3([H])[C@@]([C@H](C1)O)([H])[C@@]4(C(C([2H])([2H])C3)=C([2H])C(C([2H])([2H])C4)=O)C

Molecular Formula

C21H23D7O5

Molecular Weight

369.50

Precautions

H360, H373

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Förster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586 (7) :1937-49.|[3]Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108 (2) :242-9.|[4]Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107 (5) :776-84.