Desethylamiodarone (hydrochloride)

Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2][3].

Product Specifications

CAS Number

[96027-74-6]

Product Name Alternative

N-desethylamiodarone (hydrochloride) ; LB 33020 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H315, H319, H335, H351, H362, H410

Target

Autophagy; Potassium Channel

Type

Reference compound

Related Pathways

Autophagy; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/desethylamiodarone-hydrochloride.html

Purity

99.0

Solubility

Ethanol : 5 mg/mL (ultrasonic; warming)

Smiles

O=C(C1=C(CCCC)OC2=CC=CC=C12)C3=CC(I)=C(OCCNCC)C(I)=C3.[H]Cl

Molecular Formula

C23H26ClI2NO3

Molecular Weight

653.72

Precautions

H315, H319, H335, H351, H362, H410

References & Citations

[1]Shayeganpour A, et al. Determination of the enzyme (s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms. Drug Metab Dispos. 2006 Jan;34 (1) :43-50.|[2]Singh, B.N. and E.M. Vaughan Williams, The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br J Pharmacol, 1970. 39 (4) : p. 657-67.|[3] Rosenbaum, M.B., et al., Clinical efficacy of amiodarone as an antiarrhythmic agent. Am J Cardiol, 1976. 38 (7) : p. 934-44.