NT-0249
NT-0249 is an orally active NLRP3 inhibitor. NT-0249 has anti-inflammatory activity[1]
Product Specifications
CAS Number
2763617-39-4
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nt-0249.html
Solubility
10 mM in DMSO
Smiles
O=C([N-]S(N(C1=CN(C)N=C1)C[C@@H]2CCCO2)(=O)=O)NC3=C4C(CCC4)=CC5=C3CCC5.[Na+]
Molecular Formula
C22H28N5NaO4S
Molecular Weight
481.54
References & Citations
[1]Thornton P, et al. Reversal of High Fat Diet-Induced Obesity, Systemic Inflammation, and Astrogliosis by the NLRP3 Inflammasome Inhibitors NT-0249 and NT-0796. J Pharmacol Exp Ther. 2024 Feb 15;388 (3) :813-826.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
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