ZD7288

ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker[1].

Product Specifications

CAS Number

[133059-99-1]

Product Name Alternative

ICI D7288

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HCN Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ZD7288.html

Purity

99.77

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

[H]Cl.C/N=C1C=C(N(CC)C2=CC=CC=C2)N=C(C)N/1C

Molecular Formula

C15H21ClN4

Molecular Weight

292.81

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang XX, et al. ZD7288, a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity. Neural Regen Res. 2016 May;11 (5) :779-86.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Curated Selection

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