ZD7288
ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker[1].
Product Specifications
CAS Number
133059-99-1
Product Name Alternative
ICI D7288
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HCN Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ZD7288.html
Purity
99.77
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL
Smiles
[H]Cl.C/N=C1C=C(N(CC)C2=CC=CC=C2)N=C(C)N/1C
Molecular Formula
C15H21ClN4
Molecular Weight
292.81
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang XX, et al. ZD7288, a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity. Neural Regen Res. 2016 May;11 (5) :779-86.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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