Desogestrel

Desogestrel (Org-2969) is a third-generation progesterone analogue contained in many oral contraceptive preparations. Desogestrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1][2][3][4].

Product Specifications

CAS Number

[54024-22-5]

Product Name Alternative

Org-2969

UNSPSC

12352211

Hazard Statement

H410

Target

Progesterone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Desogestrel.html

Purity

99.42

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

[H][C@@]12C(CC[C@]([C@@](CC[C@@]3(O)C#C)([H])[C@]3(CC)C4)([H])[C@]2([H])C4=C)=CCCC1

Molecular Formula

C22H30O

Molecular Weight

310.47

Precautions

H410

References & Citations

[1]Gassen DT, et al. Evaluation of hormonal suppression with two contraceptive regimens using ethinyl estradiol and desogestrel. Arch Gynecol Obstet. 2013 Feb;287 (2) :289-94.|[2]Rosenberg MJ, et al. The effect of desogestrel, gestodene, and other factors on spotting and bleeding. Contraception. 1996 Feb;53 (2) :85-90.|[3]Barkfeldt J, et al. The effects of two progestogen-only pills containing either desogestrel (75 microg/day) or levonorgestrel (30 microg/day) on lipid metabolism. Contraception. 2001 Nov;64 (5) :295-9.|[4]Grandi G, et al. Pharmacokinetic evaluation of desogestrel as a female contraceptive. Expert Opin Drug Metab Toxicol. 2014 Jan;10 (1) :1-10.|[5]Cardani S, et al., Desogestrel down-regulates PHOX2B and its target genes in progesterone responsive neuroblastoma cells. Exp Cell Res. 2018 Sep 15;370 (2) :671-679.|[6]Xie H, et al., Effect of progestin on thyroid function in female Wistar rats. Front Endocrinol (Lausanne) . 2024 Jun 5;15:1362774.