Buformin (hydrochloride)
Buformin hydrochloride (1-Butylbiguanide hydrochloride), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin hydrochloride decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin hydrochloride also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al) [1].
Product Specifications
CAS Number
1190-53-0
Product Name Alternative
1-Butylbiguanide (hydrochloride)
UNSPSC
12352211
Hazard Statement
H302, H315, H318, H335
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/buformin-hydrochloride.html
Purity
99.91
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
NC(NC(NCCCC)=N)=N.[H]Cl
Molecular Formula
C6H16ClN5
Molecular Weight
193.68
Precautions
H302, H315, H318, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Clin Sci. 2022 Feb 25;136 (4) :273-289.|Mol Metab. 2024 Jan:79:101860.|ACS Appl Nano Mater. 2023 Oct 26.
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