NMS-P715
NMS-P715 is a selective, ATP-competitive inhibitor of MPS1, with an IC50 of 182 nM.
Product Specifications
CAS Number
1202055-32-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Mps1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NMS-P715.html
Purity
99.30
Solubility
DMSO : 2 mg/mL (ultrasonic)
Smiles
O=C(C1=NN(C)C2=C1CCC3=C2N=C(NC4=CC=C(C(NC5CCN(CC5)C)=O)C=C4OC(F)(F)F)N=C3)NC6=C(CC)C=CC=C6CC
Molecular Formula
C35H39F3N8O3
Molecular Weight
676.73
Precautions
H302, H315, H319, H335
References & Citations
[1]Colombo R, et al. Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase. Cancer Res. 2010 Dec 15;70 (24) :10255-64.|[2]Slee RB, et al. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715. Mol Cancer Ther. 2014 Feb;13 (2) :307-315.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY424431 100 µg
EP2 (PTGER2) (NM_000956) Human Over-expression Lysate
Sign In for Pricing
View Details 
KN420558 1 Kit
Mineralocorticoid Receptor (NR3C2) Human Gene Knockout Kit (CRISPR)
Sign In for Pricing
View Details 
BNC880745-500 1x 500 µL
CD45 / LCA (2B11 + PD7/26), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details