NMS-P715

NMS-P715 is a selective, ATP-competitive inhibitor of MPS1, with an IC50 of 182 nM.

Product Specifications

CAS Number

[1202055-32-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Mps1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NMS-P715.html

Purity

99.30

Solubility

DMSO : 2 mg/mL (ultrasonic)

Smiles

O=C(C1=NN(C)C2=C1CCC3=C2N=C(NC4=CC=C(C(NC5CCN(CC5)C)=O)C=C4OC(F)(F)F)N=C3)NC6=C(CC)C=CC=C6CC

Molecular Formula

C35H39F3N8O3

Molecular Weight

676.73

Precautions

H302, H315, H319, H335

References & Citations

[1]Colombo R, et al. Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase. Cancer Res. 2010 Dec 15;70 (24) :10255-64.|[2]Slee RB, et al. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715. Mol Cancer Ther. 2014 Feb;13 (2) :307-315.