Morroniside
Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.
Product Specifications
CAS Number
25406-64-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; MMP; Pyroptosis
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Morroniside.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H]([C@@H](O)[C@@H]1O)[C@](O[C@@H]1CO)([H])O[C@H]2[C@@]([C@@H]3C)([H])[C@@](C[C@H](O)O3)([H])C(C(OC)=O)=CO2
Molecular Formula
C17H26O11
Molecular Weight
406.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Zeng G, et al. Morroniside protects against cerebral ischemia/reperfusion injury by inhibiting neuron apoptosis and MMP2/9 expression. Exp Ther Med. 2018 Sep;16 (3) :2229-2234.|[2]Park CH, et al. Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice. Biol Pharm Bull. 2011;34 (10) :1559-65.|[3]Huan Yu, et al. Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling. J Ethnopharmacol. 2021 Feb 10;266:113447.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
MMP-2; MMP-9
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