K777 (tosylate)
K777 tosylate is a potent, orally active and irreversible cysteine protease inhibitor. K777 tosylate is also a potent CYP3A4 inhibitor with an IC50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 tosylate irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 tosylate is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 tosylate inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively[1][2][3].
Product Specifications
CAS Number
502960-91-0
UNSPSC
12352005
Target
Cathepsin; CCR; Cytochrome P450; Filovirus; Parasite; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/k777-tosylate.html
Smiles
O=S(O)(C1=CC=C(C=C1)C)=O.O=S(/C=C/[C@H](CCC2=CC=CC=C2)NC([C@@H](NC(N3CCN(CC3)C)=O)CC4=CC=CC=C4)=O)(C5=CC=CC=C5)=O
Molecular Formula
C39H46N4O7S2
Molecular Weight
746.94
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Frequently Asked Questions
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