JMV 2959
JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM.
Product Specifications
CAS Number
925238-89-7
UNSPSC
12352005
Target
GHSR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/JMV_2959.html
Purity
99.91
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N[C@@H](C1=NN=C(CCC2=CC=CC=C2)N1CC3=CC=C(OC)C=C3)CC4=CNC5=C4C=CC=C5)CN
Molecular Formula
C30H32N6O2
Molecular Weight
508.61
References & Citations
[1]Moulin A, et al. The 1,2,4-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959, a potent antagonist. Amino Acids. 2013 Feb;44 (2) :301-14.|[2]Engel JA, et al. Blockade of growth hormone secretagogue receptor 1A signaling by JMV 2959 attenuates the NMDAR antagonist, phencyclidine-induced impairments in prepulse inhibition. Psychopharmacology (Berl) . 2015 Dec;232 (23) :4285-92.|[3]Clifford PS, et al. Attenuation of cocaine-induced locomotor sensitization in rats sustaining genetic or pharmacologic antagonism of ghrelin receptors. Addict Biol. 2012 Nov;17 (6) :956-63.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Peptides. 2022 May:151:170763.|Nat Commun. 2025 Mar 15;16 (1) :2568.|Univerzita Karlova v Praz. 2021 Oct.
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