WDR5 degrader-1
WDR5 degrader-1 (compound 25) is a cereblon (CRBN) -recruiting WDR5 degrader. WDR5 degrader-1 selectively degraded WDR5 over the CRBN neo-substrate IKZF1[1].
Product Specifications
CAS Number
[3032434-45-7]
UNSPSC
12352005
Target
PROTACs; WDR5
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wdr5-degrader-1.html
Purity
98.00
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1[C@@H](CN(C2=C(C=C(C=C2)C3=CC(C(NCCCCCCCNC(COC4=C(C5=CC=C4)C(N(C5=O)C6C(NC(CC6)=O)=O)=O)=O)=O)=CC=C3F)NC(C7=CNC(C=C7C(F)(F)F)=O)=O)C[C@@H]1C)C
Molecular Formula
C49H52F4N8O9
Molecular Weight
972.98
References & Citations
[1]Xufen Yu, et al. Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer. J Med Chem. 2023, 66, 23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
