WDR5 degrader-1
Product Specifications
UNSPSC Description
WDR5 degrader-1 (compound 25) is a cereblon (CRBN)-recruiting WDR5 degrader. WDR5 degrader-1 selectively degraded WDR5 over the CRBN neo-substrate IKZF1[1].
Target Antigen
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wdr5-degrader-1.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1[C@@H](CN(C2=C(C=C(C=C2)C3=CC(C(NCCCCCCCNC(COC4=C(C5=CC=C4)C(N(C5=O)C6C(NC(CC6)=O)=O)=O)=O)=O)=CC=C3F)NC(C7=CNC(C=C7C(F)(F)F)=O)=O)C[C@@H]1C)C
Molecular Weight
972.98
References & Citations
[1]Xufen Yu, et al. Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer. J Med Chem. 2023, 66, 23.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162014/WDR5-degrader-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162014/WDR5-degrader-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
3032434-45-7
Available Sizes
Curated Selection
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