Byakangelicin

Byakangelicin, one of the active compounds found in the roots of Angelica gigas, can serve as a modulator to improve brain accumulation of diverse active compounds (Umb, Cur, and Dox) and enhance therapeutic effects[1]. Byakangelicin is likely to increase the expression of all PXR target genes (such as MDR1) and induce a wide range of agent-agent interactions. Byakangelicin can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones[2].

Product Specifications

CAS Number

[482-25-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/byakangelicin.html

Purity

99.94

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C)(O)[C@H](O)COC1=C(OC=C2)C2=C(OC)C(C=C3)=C1OC3=O

Molecular Formula

C17H18O7

Molecular Weight

334.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Kang YY, et al. Byakangelicin as a modulator for improved distribution and bioactivity of natural compounds and synthetic drugs in the brain. Phytomedicine. 2019 May 17;62:152963.|[2]Yang J, et al. Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes. Br J Pharmacol. 2011 Jan;162 (2) :441-51.