ALC67
ALC67 is a cytotoxic thiazolidine compound with an IC50 of approximately 5 μM against liver, breast cancer, colon cancer, and endometrial cancer cell lines. ALC67 induces apoptosis in cancer cells by activating caspase-9 and causing cell cycle arrest at the SubG1/G1 phase, via a pathway that is independent of death receptors. ALC67 can be used in cancer research[1].
Product Specifications
CAS Number
[1044255-57-3]
UNSPSC
12352005
Target
Apoptosis; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alc67.html
Smiles
O=C([C@H]1N(C(C#C)=O)C(C2=CC=CC=C2)SC1)OCC
Molecular Formula
C15H15NO3S
Molecular Weight
289.35
References & Citations
[1]Onen-Bayram FE, et al. A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells. Bioorg Med Chem. 2012 Sep 1;20 (17) :5094-102.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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