ALC67

ALC67 is a cytotoxic thiazolidine compound with an IC50 of approximately 5 μM against liver, breast cancer, colon cancer, and endometrial cancer cell lines. ALC67 induces apoptosis in cancer cells by activating caspase-9 and causing cell cycle arrest at the SubG1/G1 phase, via a pathway that is independent of death receptors. ALC67 can be used in cancer research[1].

Product Specifications

CAS Number

[1044255-57-3]

UNSPSC

12352005

Target

Apoptosis; Caspase

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/alc67.html

Smiles

O=C([C@H]1N(C(C#C)=O)C(C2=CC=CC=C2)SC1)OCC

Molecular Formula

C15H15NO3S

Molecular Weight

289.35

References & Citations

[1]Onen-Bayram FE, et al. A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells. Bioorg Med Chem. 2012 Sep 1;20 (17) :5094-102.