Estrogen receptor modulator 1

Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. Estrogen receptor modulator 1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors[1][2].

Product Specifications

CAS Number

[63676-22-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/estrogen-receptor-modulator-1.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C=C(C2=CC=C(O)C=C2)S3)C3=C1

Molecular Formula

C14H10O2S

Molecular Weight

242.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Brogi S, et al. 3D-QSAR using pharmacophore-based alignment and virtual screening for discovery of novel MCF-7 cell line inhibitors. Eur J Med Chem. 2013 Sep;67:344-51.|[2]Molloy ME, et al. Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer. Mol Cancer Ther. 2014 Nov;13 (11) :2515-26.