P053
P053 is a potent, non-competitive and selective ceramide synthase 1 (CerS1) inhibitor wirh an IC50 of 0.5 μM. P053 acts as an endogenous inhibitor of mitochondrial fatty acid oxidation in muscle. Whole-body adiposity regulator[1].
Product Specifications
CAS Number
[2748196-63-4]
UNSPSC
12352005
Target
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/p053.html
Purity
97.0
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC[C@@](C)(N)CCC1=CC=C(OCC2=CC=C(Cl)C(Cl)=C2)C=C1
Molecular Formula
C18H21Cl2NO2
Molecular Weight
354.27
References & Citations
[1]Turner N, et al. A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism. Nat Commun. 2018 Aug 21;9 (1) :3165.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Mouse Monoclonal Fc gamma RI/CD64 Antibody (32.2-1A) [Janelia Fluor 525]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
Mouse Monoclonal Fc gamma RI/CD64 Antibody (32.2-1A) [Janelia Fluor 525]
N⁶- (3- Methylbenzyl) adenosine- 5'- O- diphosphate (6- (3-MeBn) -ADP), sodium salt
