Anti-Neurturin Antibody

Rabbit Polyclonal Antibody specific to Neurturin

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Anti-Neurturin Rabbit Polyclonal Antibody

Gene Name

NRTN

Gene ID

4902

NCBI Gene ID

UniProt

Q99748

Accession Number

NP_004549

Cellular Locus

Secreted.

Host

Rabbit

Reactivity

Human

Immunogen

Peptide corresponding to aa 178-193 of human neurturin.

Target Antigen

Neurturin

Target

Neurturin

Clonality

Polyclonal

Isotype

IgG

Type

Antibody

Applications

ELISA, WB, IHC-P, IF

Field of Research

Neuroscience

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.

Additionnal Information

Immunoblotting: use at 1:500 dilution.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Specificity

This antibody recognizes human, neurturin (14 kD).

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

Glial cell line-derived neurotrophic factor (GDNF) plays a key role in the conrol of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. (NTN). Physiological responses to NTN require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRalpha. The cDNAS encoding NTNRalpha from human, rat, chicken, and mouse have been cloned and referred to as GFRalpha-2, GDNFRbeta, Ret ligand 2 (RETL2), and TGF-beta-related neurotrophic factor receptor 2 (TmR2). NTN forms a complex with GFRalpha-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations.