Ebiratide (TFA)

Ebiratide (HOE-427) TFA is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory-enhancing efficacy. Ebiratide TFA enhances acetycholine (ACh) metabolism in rat brain[1][2].

Product Specifications

Product Name Alternative

HOE-427 (TFA)

UNSPSC

12352209

Target

NAChR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ebiratide-tfa.html

Purity

99.04

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

NCCCCCCCCNC([C@H](CC1=CC=CC=C1)NC([C@@H](CCCCN)NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](N)CCS(C)(=O)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C48H73N11O10S.xC2HF3O2

Molecular Weight

996.23 (free base)

References & Citations

[1]Hock FJ, et al., Learning and memory processes of an ACTH4-9 analog (ebiratide; Hoe 427) in mice and rats. Peptides. 1988 May-Jun;9 (3) :575-81. |[2]G Wiemer, et al. Neurochemical effects of the synthetic ACTH4-9-analog Hoe 427 (Ebiratide) in rat brain. Peptides. 1988 Sep-Oct;9 (5) :1081-7.