Tricarbonyldichlororuthenium (II) dimer

Tricarbonyldichlororuthenium (II) dimer (CORM-2) is a CO-releasing molecule. Tricarbonyldichlororuthenium (II) dimer exhibits anti-inflammatory, antioxidant, and gastric mucosa-protective activities. Additionally, Tricarbonyldichlororuthenium (II) dimer has CO-independent functional effects on multiple potassium channels[1][2][3][4].

Product Specifications

CAS Number

[22594-69-0]

Product Name Alternative

CORM-2

UNSPSC

12352300

Hazard Statement

H302, H315, H319, H335

Target

Interleukin Related; NO Synthase; P2X Receptor; Potassium Channel; STAT

Type

Reference compound

Related Pathways

Immunology/Inflammation; JAK/STAT Signaling; Membrane Transporter/Ion Channel; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tricarbonyldichlororuthenium-ii-dimer.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 30 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

[O]#C[Ru+2](C#[O])([Cl-])([Cl-][Ru+2]1(C#[O])(C#[O])([Cl-])C#[O])([Cl-]1)C#[O]

Molecular Formula

C6H6Cl4O6Ru2

Molecular Weight

512.01

Precautions

H302, H315, H319, H335

References & Citations

[1]Magierowska K, et, al. Oxidative gastric mucosal damage induced by ischemia/reperfusion and the mechanisms of its prevention by carbon monoxide-releasing tricarbonyldichlororuthenium (II) dimer. Free Radic Biol Med. 2019 Dec; 145:198-208.|[2]Dong DL, et al. Tricarbonyldichlororuthenium (II) dimer (CORM2) activates non-selective cation current in human endothelial cells independently of carbon monoxide releasing. Eur J Pharmacol. 2008 Aug 20;590 (1-3) :99-104.|[3]Gessner G, et al. CO-independent modification of K+ channels by tricarbonyldichlororuthenium (II) dimer (CORM-2) . Eur J Pharmacol. 2017 Nov 15;815:33-41.|[4]Choi EY, et al. Tricarbonyldichlororuthenium (II) dimer, the lipid-soluble carbon monoxide-releasing molecule, attenuates Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-1β in murine macrophages. Int Immunopharmacol. 2021 Jan;90:107190.