Crotonoside
Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the research of AML[1].
Product Specifications
CAS Number
1818-71-9
Product Name Alternative
Isoguanosine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
FLT3; HDAC
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/crotonoside.html
Purity
99.78
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC(C(N)=N3)=C2NC3=O)O1)O)O
Molecular Formula
C10H13N5O5
Molecular Weight
283.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Li YZ, et al. Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6. Oncotarget. 2017 Sep 8;8 (61) :103087-103099.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HDAC3; HDAC6
Available Sizes
Frequently Asked Questions
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