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Crotonoside

Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the research of AML[1].

Product Specifications

CAS Number

[1818-71-9]

Product Name Alternative

Isoguanosine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

FLT3; HDAC

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/crotonoside.html

Purity

99.78

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC(C(N)=N3)=C2NC3=O)O1)O)O

Molecular Formula

C10H13N5O5

Molecular Weight

283.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Li YZ, et al. Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6. Oncotarget. 2017 Sep 8;8 (61) :103087-103099.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

HDAC3; HDAC6

Available Sizes

Curated Selection

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