FR900359

FR900359 is a depsipeptide selective inhibitor of Gαq/11/14 in mammalia, can inhibits ERK pathway. FR900359 suppresses the proliferation of melanoma cells and decreases of blood pressure. FR900359 also protected against airway hyperreactivity in murine models of allergen sensitization in Ovalbumins (HY-W250978) –induced sensitization model of asthma. FR900359 can be used for cancer and cardiovascular disease research[1][2][3][4].

Product Specifications

CAS Number

[107530-18-7]

UNSPSC

12352005

Hazard Statement

H225, H302+H312+H332, H319

Target

Apoptosis; ERK

Type

Natural Products

Related Pathways

Apoptosis; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/fr900359.html

Purity

99.90

Solubility

10 mM in DMSO

Smiles

CC(C)[C@@H](O)[C@H](NC(CC)=O)C(O[C@@H]([C@H](NC([C@H](C)N(C)C([C@H](C)NC(C(N(C)C([C@@H](CC1=CC=CC=C1)O2)=O)=C)=O)=O)=O)C(N(C)[C@@H]([C@H](OC)C)C(O[C@H](C(C)C)[C@H](NC(C)=O)C2=O)=O)=O)C(C)C)=O

Molecular Formula

C49H75N7O15

Molecular Weight

1002.16

Precautions

H225, H302+H312+H332, H319

References & Citations

[1]Schrage R, et.al. The experimental power of FR900359 to study Gq-regulated biological processes. Nat Commun. 2015 Dec 14;6:10156. |[2]Fujioka, M, et.al. Structure of FR900359, a cyclic depsipeptide from Ardisia crenata sims J. Org. Chem. 1988, 53 (12), 2820−2825. |[3]Lapadula D, et.al. Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma. Mol Cancer Res. 2019 Apr;17 (4) :963-973. |[4]Matthey M, et.al. Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma. Sci Transl Med. 2017 Sep 13;9 (407) :eaag2288.