GGGDTDTC-Mc-vc-PAB-MMAE

GGGDTDTC-Mc-vc-PAB-MMAE is a Drug-Linker Conjugate for ADC, containing a tubulin inhibitor Monomethyl auristatin E (MMAE, HY-15162) [1].

Product Specifications

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC; Microtubule/Tubulin

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gggdtdtc-mc-vc-pab-mmae.html

Purity

99.75

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N2[C@@]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C3=CC=CC=C3)=O)([H])CCC2)=O)C)=O)=O)=O)C=C1)=O)=O)NC(CCCCCN4C(C(SC[C@@H](C(N)=O)NC([C@H]([C@H](O)C)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CC(O)=O)NC(CNC(CNC(CN)=O)=O)=O)=O)=O)=O)=O)CC4=O)=O)=O

Molecular Formula

C93H146N20O29S

Molecular Weight

2040.34

References & Citations

[1]Zhao YJ, et al. Nanobody drug conjugate with high activity and application of GALA polypeptide in antibody drug conjugate. China, CN112807444 A. 2021-05-18.