155H1
155H1 (Compound 11) is a stapled peptide, that covalently binds hMcl1 (172-323) with IC50 of 18 nM[1].
Product Specifications
UNSPSC
12352209
Target
Bcl-2 Family
Type
Peptides
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/155h1.html
Solubility
10 mM in DMSO
Smiles
NC(NCCC[C@H](NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@@H](NC([C@H](CNC(C1=C(OC)C=CC(S(=O)(F)=O)=C1)=O)NC(C)=O)=O)[C@H](CC)C)=O)=O)=O)=O)=O)C(N[C@]2(CCC/C=C\CCC[C@@](C)(C(N[C@@H](CC3=CC=CC=C3)C(N)=O)=O)NC([C@H](CC(O)=O)NC(CNC([C@H]([C@@H](C)CC)NC2=O)=O)=O)=O)C)=O)=N
Molecular Formula
C79H120FN19O23S
Molecular Weight
1754.98
References & Citations
[1]Alboreggia G, et al., Histidine-Covalent Stapled Alpha-Helical Peptides Targeting hMcl-1. J Med Chem. 2024 May 23;67 (10) :8172-8185.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Curated Selection
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