Monobenzone

Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and exhibits good potential for vitiligo research. Monobenzone is a potent inhibitor of RNR (Ribonucleotide reductase) enzyme activity by targeting RRM2 (a regulatory small subunit M2 of RNR) protein, and thus has significant anti-leukemia efficacy in vitro and in vivo. Monobenzone inhibits acute myeloid leukemia (AML) cells proliferation and DNA synthesis, induces cell cycle arrest, and Apoptosis [1][2].

Product Specifications

CAS Number

[103-16-2]

UNSPSC

12352005

Hazard Statement

H317, H319

Target

Apoptosis; Biochemical Assay Reagents; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-_Benzyloxy_phenol.html

Purity

99.98

Solubility

DMSO : ≥ 100 mg/mL|Methanol : 400 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C=C1)OCC2=CC=CC=C2

Molecular Formula

C13H12O2

Molecular Weight

200.24

Precautions

H317, H319

References & Citations

[1]Zhu Y, et al. A mouse model of vitiligo induced by monobenzone. Exp Dermatol. 2013 Jul;22 (7) :499-501. doi: 10.1111/exd.12184.|[2]Dong J, et al. Identification of Monobenzone as a Novel Potential Anti-Acute Myeloid Leukemia Agent That Inhibits RNR and Suppresses Tumour Growth in Mouse Xenograft Model. Cancers (Basel) . 2022 Sep 27;14 (19) :4710.