JNK-1-IN-4
Product Specifications
UNSPSC Description
JNK-1-IN-4 (Compound E1) is an inhibitor for JNK, that inhibits JNK-1, JNK-2 and JNK-3 with IC50s of 2.7, 19.0 and 9.0 nM, respectively. JNK-1-IN-4 inhibits the phosphorylation of c-Jun, and reduces the expression of TGF-β1-induced EMT marker proteins, such as fibronectin and α-SMA. JNK-1-IN-4 exhibits good pharmacokinetic characteristics with a bioavailability of 69%. JNK-1-IN-4 exhibits anti-fibrotic effect in Bleomycin (HY-17565)-induced mice idiopathic pulmonary fibrosis models[1].
Target Antigen
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jnk-1-in-4.html
Smiles
COC1=CC=C(NC2=NC(NC3=CC=C(OCCN(C)C)C=C3C(N)=O)=C(Br)C=N2)C=C1
Molecular Weight
501.38
References & Citations
[1]Huang Y, et al., Structure Optimization of c-Jun N-terminal Kinase 1 Inhibitors for Treating Idiopathic Pulmonary Fibrosis. J Med Chem. 2024 Oct 10;67(19):17713-17737.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169177/JNK-1-IN-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169177/
Clinical Information
No Development Reported
CAS Number
3047795-60-5
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
IRBAHUCD44AP172120UL 120 µL
Rabbit Anti Human CD44 Polyclonal Affinity Purified (PBS with 0.05% sodium azide and 50% glycerol, pH7.4) (Western Blot,ELISA) 120ul
Ask
View Details