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UAA crosslinker 1 (hydrochloride)

Product Specifications

UNSPSC Description

UAA crosslinker 1 hydrochloride is an amber codon used for non-canonical amino acids (ncAAs) incorporation. The ncAAs can be incorporated into proteins in vivo by making use of the promiscuous activity of certain wildtype and engineered aminoacyl-tRNA synthetases[1]. UAA crosslinker 1 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Target Antigen

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/uaa-crosslinker-1-hydrochloride.html

Purity

98.0

Solubility

DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 100 mg/mL (ultrasonic)

Smiles

N[C@@H](CCCCNC(OCCN=[N+]=[N-])=O)C(O)=O.[H]Cl

Molecular Weight

295.72

References & Citations

[1]Kofoed C, et al. Semisynthesis of an Active Enzyme by Quantitative Click Ligation. Bioconjug Chem. 2019 Apr 17;30(4):1169-1174.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-111434A/UAA-crosslinker-1-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-111434A/UAA-crosslinker-1-hydrochloride-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

1994331-17-7

Available Sizes

Curated Selection

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