UAA crosslinker 1 (hydrochloride)
UAA crosslinker 1 hydrochloride is an amber codon used for non-canonical amino acids (ncAAs) incorporation. The ncAAs can be incorporated into proteins in vivo by making use of the promiscuous activity of certain wildtype and engineered aminoacyl-tRNA synthetases[1]. UAA crosslinker 1 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Product Specifications
CAS Number
[1994331-17-7]
UNSPSC
12352211
Hazard Statement
H242
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/uaa-crosslinker-1-hydrochloride.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)
Smiles
N[C@@H](CCCCNC(OCCN=[N+]=[N-])=O)C(O)=O.[H]Cl
Molecular Formula
C9H18ClN5O4
Molecular Weight
295.72
Precautions
H242
References & Citations
[1]Kofoed C, et al. Semisynthesis of an Active Enzyme by Quantitative Click Ligation. Bioconjug Chem. 2019 Apr 17;30 (4) :1169-1174.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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