α, β-Methylene-ATP (trisodium)

α, β-Methylene-ATP trisodium is an agonist of P2X1 and P2X3 receptors and can cross the blood-brain barrier. α, β-Methylene-ATP trisodium can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC) ; this effect can be blocked by the P2X antagonist PPADS (HY-108960) . α, β-Methylene-ATP trisodium also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects; this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602) . α, β-Methylene-ATP trisodium can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system[1][2][3].

Product Specifications

CAS Number

[1343364-54-4]

UNSPSC

12352005

Target

P2X Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/α-β-methylene-atp-trisodium.html

Purity

99.75

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O=P(O)([O])OP(CP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1)(O[Na])=O)(O[Na])=O.[Na]

Molecular Formula

C11H15N5Na3O12P3

Molecular Weight

571.15

References & Citations

[1]Arribas-Blázquez M, et al. Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain. Int J Mol Sci. 2019 Jan 3;20 (1) .|[2]Hanna RL, et al. alpha, beta-Methylene ATP elicits a reflex pressor response arising from muscle in decerebrate cats. J Appl Physiol (1985) . 2002 Sep;93 (3) :834-41.|[3]Fukui M, et al. Involvement of locus coeruleus noradrenergic neurons in supraspinal antinociception by alpha, beta-methylene-ATP in rats. J Pharmacol Sci. 2004 Feb;94 (2) :153-60