S-Adenosylhomocysteine sulfoxide

S-Adenosylhomocysteine sulfoxide is an inhibitor of catechol-O-methyltransferase (COMT) with an IC50 value of 860 μM. S-Adenosylhomocysteine sulfoxide can be used in the research of methylation reaction modulators[1].

Product Specifications

CAS Number

[29907-86-6]

UNSPSC

12352005

Target

COMT

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/s-adenosylhomocysteine-sulfoxide.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CS(CC[C@@H](C(O)=O)N)=O)O3

Molecular Formula

C14H20N6O6S

Molecular Weight

400.41

References & Citations

[1]Coward J K, et al. Inhibition of catechol-O-methyltransferase by S-adenosylhomocysteine and S-adenosylhomocysteine sulfoxide, a potential transition-state analog[J]. Biochemical pharmacology, 1972, 21 (8) : 1200-1203.